Usually no treatment for mono is needed other than self-care at home.
Most people recover from mono after several weeks. But for some, it may take several months before they regain their normal energy levels. This extended period of fatigue is not the same as having chronic fatigue syndrome.
In severe cases, corticosteroids may be used to reduce swelling of the throat, tonsils, or spleen. This type of steroid use may also decrease the overall length and severity of illness from infectious mono.