Chronic Inflammation – Particularly TNF-alpha and Interleukin 1 (R, R2).
Aging – Aldosterone levels naturally decline with age ®.
Age-related hearing loss – Also associated with age-related Potassium depletion ®.
Addison’s Disease – A disease of inefficient steroid hormone production ®.
Aldosterone increases CD8+ cells ®, so it can be good for controlling viral infections like EBV. Therefore, it could potentially help people with Chronic Fatigue Syndrome.
Aldosterone may also be beneficial for some types of inflammation like Uveitis (in animal models) ® and may block the Nf-kB-induced TNF-alpha in blood cells ®.
Aldosterone is required for the body to make cysteine dioxygenase, which is important for the Sulfation pathway of Phase 2 detoxification. Sulfation is the addition of a sulfate to a drug/toxin and most often it makes it less toxic.
Chronic inflammation in the form of TNF and TGF-b decreases the enzyme that turns cysteine to sulfate (cysteine dioxygenase), which results in higher cysteine and lower sulfate.
Normally, aldosterone increases calcium reabsorption ®.