Methotrexate interferes with DNA synthesis and has more of an effect against cells that are proliferating faster than normal (these types of cells typically occur in cancer and psoriasis). However, other cells located in bone marrow, the gastrointestinal tract, in a developing fetus, and the bladder are also sensitive to methotrexate’s effect.
Experts are not sure how methotrexate works in rheumatoid arthritis but believe it may affect immune function.
Effective for people with severe, disabling psoriasis or rheumatoid arthritis that is not responsive to other forms of treatment.
May be used in the treatment of some life-threatening cancers including osteosarcoma, hydatidiform mole, and acute lymphocytic leukemia.