Allergic reactions
Tongue inflammation may occur if you have an allergic reaction to toothpaste, mouthwash, dentures, denture creams, or retainers. Allergic reactions to certain medications may also cause this condition.
Sjögren’s syndrome
This condition results in the destruction of the saliva glands. When this occurs, you may develop dry mouth, which in turn can lead to tongue inflammation.
Skin conditions
Certain skin conditions may cause tongue inflammation. Oral lichen planus is an inflammatory disease causing sores, swelling, and redness. Syphilis is a sexually transmitted infection that can present as a body rash. Pemphigus is an autoimmune disease that causes skin blistering.