There are more than 100 different forms of arthritis and related diseases. The most common types include osteoarthritis (OA), rheumatoid arthritis (RA), psoriatic arthritis (PsA), fibromyalgia and gout. All of them cause pain in different ways.
In osteoarthritis (OA), the protective cartilage inside the joint breaks down. This makes movement of affected joints more difficult and painful. In time, bones of the joint may rub directly against one another, causing severe pain. Pain can also come from parts of your joint other than the cartilage, such as bone, synovium and ligaments. The intensity of OA pain varies from person to person and can range from mild to severe. You can read more about sources of OA pain and pain treatments in our Breaking the Arthritis Pain Chain toolkit.
In rheumatoid arthritis (RA), the joints and other organs are attacked by the body’s own immune system. The immune system normally protects a person from viruses, bacteria and other invaders. In people with autoimmune diseases like RA, it becomes overactive and attacks healthy tissue. In the case of RA, the immune system primarily goes after the lining of the joints, called the synovium. Over time, the persistent inflammation breaks down the joint and damages it permanently.
Pain in RA can come from other parts of your joint besides the synovium, such as bone and ligaments. You can read more about sources of inflammatory pain and its treatments in Breaking the Arthritis Pain Chain toolkit.
Psoriatic arthritis (PsA) is an autoimmune inflammatory disease in which the immune system attacks the body, causing inflammation and pain. PsA affects the joints, causing arthritis; the connective tissue where tendons or ligaments attach to bones, causing enthesitis; and the skin, causing psoriasis. You can read more about sources of inflammatory pain and its treatments in Breaking the Arthritis Pain Chain toolkit.
Fibromyalgia is considered a central pain syndrome. This means that the brain and spinal cord process pain signals differently. A touch or movement that doesn’t cause pain for others may feel painful to you (this is called allodynia). Something that is mildly painful to someone without fibromyalgia may hurt you even more (this is called hyperalgesia).
Fibromyalgia is characterized by widespread pain. It may come and go or be constant. Besides pain, fibromyalgia is associated with other symptoms, such as fatigue, sleep problems, inability to concentrate and mood troubles. Learn more about centralized pain and its treatments in Breaking the Arthritis Pain Chain.
Gout is a form of inflammatory arthritis, but it does not cause body-wide inflammation like RA or PsA does. In gout, uric acid crystals are the problem. If your body produces too much uric acid or if you are unable to remove the excess fast enough, it can build up in the blood (called hyperuricemia). Excess uric acid can form crystals in your joints. This results in extremely painful joint inflammation. Gout usually strikes in the large joint of the big toe, but can also affect other joints. With a gout flare, you can go to bed feeling fine and wake up with excruciating pain.
Lupus is an autoimmune inflammatory disease that affects many parts of the body, including the joints, kidneys, skin, blood, brain and other organs. It can cause joint pain, fatigue, hair loss, sensitivity to light, fever, rash and kidney problems. You can read more about sources of inflammatory pain and its treatments in Breaking the Arthritis Pain Chain toolkit.