The recommended dose of follitropin alpha varies according to individual circumstances. The goal is to use the lowest dose that is expected to achieve good results. Doses usually range from 75 IU to 450 IU (5.5 µg to 33 µg) per day.
To induce ovulation, treatment is usually started at a dose of 75 IU once daily. The dose can be increased by up to 37.5 IU by the doctor after 14 days, and then every 7 days after that. One course of treatment should not exceed 35 days under normal circumstances. Intercourse should be attempted at a consistent frequency of at least 3 times per week from the day prior to administration of hCG until ovulation becomes apparent. If there is evidence of ovulation but pregnancy does not occur, the regimen is repeated for at least 2 more courses before the dose is increased to 150 IU per day for 7 to 12 days.
For ART procedures, treatment is usually started at a dose of 150 IU or 225 IU (depending on your circumstances) once a day. After the first 5 days, your doctor may consider increasing the dose by 37.5 IU to 150 IU. Additional dose increases can be made every 3 to 5 days.
After preparation, follitropin alpha is injected either under the skin (subcutaneous) or into a muscle (intramuscular) as directed, usually into the thigh or abdomen.