what is multiple autoimmune syndrome

Multiple Autoimmune Syndrome (MAS) is the coexistence of three or more autoimmune diseases. At least one of them is usually a skin disease, such as psoriasis or scleroderma.

An unusual association of three autoimmune disorders: celiac disease (CD), systemic lupus erythematosus (SLE) and Hashimoto’s thyroiditis. This case is unusual: the rare combination of the three autoimmune diseases, their appearance in a man and the atypical onset of the diseases with psychiatric symptoms likely to be related either to CD or to SLE

Familial Aggregation and Segregation Analysis in Families Presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome. Data suggest that polyautoimmunity and MAS are not independent traits and that gender, age, and age of onset are interrelated factors influencing autoimmunity. PubMed, J Immunol Res, 2015;2015:572353. (Also see Scleroderma in Overlap)

Novel and rare functional genomic variants in multiple autoimmune syndrome (MAS) and Sjögren’s syndrome. The LRP1/STAT6 novel mutation has the strongest case for being categorised as potentially causative of MAS given the presence of intriguing patterns of functional interaction with other major genes shaping autoimmunity